With the HTR2A mutation known to exist in sufferers of sleep-related bruxism, there is a hypersensitivity to serotonin, a neurotransmitter found in the central nervous system. Certain medications work by preventing serotonin from being re-uptaken or broken down. This results in an increase in sleep-related bruxism and an increase in associated signs and symptoms.

Some examples of the medications and classes of medications known to affect sleep-related bruxism include:

Selective Serotonin Re-uptake Inhibitors:

Selective Serotonin Norepinephrine Re-uptake Inhibitors:

Both of these classes of commonly prescribed medications for depression have been shown to have sleep-related bruxism as a risk factor. If someone who carries the HTR2A polymorphism mutation takes one of the above medications, their sleep-related bruxism can be initiated or worsened. As well, even if the medication is discontinued, the sleep-related bruxism persists in more than 50% of patients.

Another medication shown to initiate or worsen sleep-related bruxism is Ritalin, a commonly used drug used to treat ADDT in children. 50% of the children carrying the HTR2A polymorphism mutation run the risk of suffering from sleep-related bruxism for life.

There are many more medications implicated in worsening sleep-related bruxism. If you suffer from sleep-related bruxism, you should be very cautious before starting any medications for depression or anxiety.